TMEM81

Across TCGA cell cohorts, TMEM81 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM81-associated genes across cancer lineages are MMP26, OR6K3, and OR10K1. Each is linked with TMEM81 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM81-to-partner and partner-to-TMEM81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by TMEM81-low versus TMEM81-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM81→partner) and Y-score (partner→TMEM81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP26 →	+0.013	+4.022	<.001	.006	3	2
OESOPHAGUS	OR6K3 →	+0.006	+4.906	<.001	.006	3	1
LARGE_INTESTINE	OR10K1 →	+0.006	+6.022	<.001	.001	3	1
LUNG_NSCLC_LUAD	CSN2 →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPRR2B →	+0.044	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	GKN2 →	+0.140	+4.169	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MMP26 by TMEM81 expression — SKIN

Explore this box plot interactively →