TMEM78

Across TCGA pan-cancer cohorts, TMEM78 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TMEM78 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM78 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM78 expression acts as an unfavorable survival marker, although some lineages such as LAML and THYM show a favorable association.

UCEC, DLBC, and KICH are the cancer types where TMEM78 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.749	0.867	<.001	62	view →
DLBC	DFS	Tertile	III,IV	0.118	0.774	<.001	45	view →
KICH	DFS	Tertile	III,IV	0.100	0.737	.012	39	view →
UVM	OS	Tertile	All	0.537	0.792	.036	27	view →
LAML	DFS	Tertile	All	0.623	0.225	.001	24	view →
PCPG	OS	Quartile	All	0.906	0.992	.005	24	view →
THCA	DFS	Quartile	IV	0.417	0.787	.004	22	view →
KIRP	DFS	Median	All	0.512	0.655	.002	18	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	15	view →
MESO	DFS	Quartile	III,IV	0.211	0.417	.007	15	view →
ACC	OS	Tertile	All	0.282	0.705	.007	12	view →
LUAD	DFS	Tertile	All	0.750	0.856	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TMEM78–UCEC (DFS)

Open the UCEC breakdown →