TMEM74B

Across TCGA pan-cancer cohorts, TMEM74B Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM74B data layer compared with 27 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TMEM74B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM74B expression acts as an unfavorable survival marker.

LUAD, LUSC, and BRCA are the cancer types where TMEM74B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.127	0.669	<.001	24	view →
LUSC	OS	Median	III,IV	0.500	0.664	<.001	16	view →
BRCA	DFS	Median	All	0.294	0.903	.002	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM74B–LUAD (OS)

Open the LUAD breakdown →