TMEM74

Across TCGA pan-cancer cohorts, TMEM74 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM74 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TMEM74 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM74 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

BLCA, CESC, and LUSC are the cancer types where TMEM74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.110	0.627	<.001	39	view →
CESC	OS	Median	II,III,IV	0.121	0.829	<.001	36	view →
LUSC	DFS	Median	All	0.936	0.651	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM74–BLCA (DFS)

Open the BLCA breakdown →