TMEM74

Across TCGA patient cohorts, TMEM74 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM74-associated genes across cancer lineages are STAT3_pY705, ATM, and Bad_pS112. Each is linked with TMEM74 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM74-to-partner and partner-to-TMEM74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TMEM74-low versus TMEM74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74→partner) and Y-score (partner→TMEM74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.582	-3.169	<.001	.020	3	2
UCEC	ATM →	-0.802	-3.169	.001	.020	3	2
LUSC	Bad_pS112 →	+0.208	+3.197	.012	.009	3	1
SKCM	Akt_pT308 →	-0.434	-2.115	.045	.018	3	1
SKCM	Smad4 →	+0.145	+2.472	.003	.010	3	1
SKCM	Chk1_pS345 →	-0.135	-2.982	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

STAT3_pY705 by TMEM74 expression — UCEC

Explore this box plot interactively →