TMEM74

Across TCGA cell cohorts, TMEM74 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,077 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM74-associated GO terms across cancer lineages are Chromosome segregation, DNA-templated transcription initiation, and Ribosome biogenesis. Each is linked with TMEM74 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM74-to-partner and partner-to-TMEM74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosome segregation grouped by TMEM74-low versus TMEM74-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM74→partner) and Y-score (partner→TMEM74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Chromosome segregation →	+0.135	+0.471	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.072	+0.399	<.001	.007	3	12
BONE	Ribosome biogenesis →	+0.096	+1.145	<.001	<.001	3	12
OESOPHAGUS	Mitotic sister chromatid segregation →	+0.145	+0.436	<.001	.004	3	11
OESOPHAGUS	Sister chromatid segregation →	+0.143	+0.436	<.001	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.097	+0.255	.006	.009	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,077 associations by consensus.

Chromosome segregation by TMEM74 expression — OESOPHAGUS

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