Across TCGA pan-cancer cohorts, TMEM72 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM72 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM72 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM72 expression acts as an unfavorable survival marker.
COAD, SCLC, and LUAD are the cancer types where TMEM72 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.