Across TCGA patient cohorts, TMEM72 protein abundance is significantly associated with the RNA expression of many other genes, with 778 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TMEM72-associated genes across cancer lineages are ESS2, KDELR3, and FBXO7. Each is linked with TMEM72 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM72-to-partner and partner-to-TMEM72 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM72→partner) and Y-score (partner→TMEM72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ESS2 →	+0.178	+0.498	.006	<.001	3	1
CCRCC	KDELR3 →	-0.864	-0.529	<.001	<.001	3	1
CCRCC	FBXO7 →	+0.291	+0.490	<.001	.008	3	1
CCRCC	TIMP3 →	+1.021	+0.569	.006	.002	3	1
CCRCC	MIOX →	+1.391	+0.456	<.001	<.001	3	1
CCRCC	DCAF11 →	+0.284	+0.553	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 778 associations by consensus.

Exploration

TMEM72 survival (RNA) · tumor vs normal (RNA) · all TMEM72 data types