TMEM72

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TMEM72 mutation is significantly associated with the RNA expression of many other genes, with 474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM72-associated genes across cancer lineages are EIF1AD, GOLGA3, and MIR1226. Each is linked with TMEM72 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM72-to-partner and partner-to-TMEM72 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM72→partner) and Y-score (partner→TMEM72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECEIF1AD →+0.481+3.362<.001.00532
UCECGOLGA3 →+0.568+3.393<.001.00432
COADMIR1226 →+0.820+5.516<.001.00432
UCECUBN1 →+0.549+3.627.003.00132
UCECDIAPH1 →+0.552+3.202.005.00932
UCECTRAJ28 →+0.790+2.939<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 474 associations by consensus.

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