TMEM71

Across TCGA cell cohorts, TMEM71 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM71-associated genes across cancer lineages are RIT2, PPP1R2C, and ST8SIA2. Each is linked with TMEM71 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM71-to-partner and partner-to-TMEM71 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by TMEM71-low versus TMEM71-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM71→partner) and Y-score (partner→TMEM71) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RIT2 →	+0.030	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PPP1R2C →	+0.037	+3.510	<.001	.003	3	1
LARGE_INTESTINE	ST8SIA2 →	+0.743	+3.716	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

RIT2 by TMEM71 expression — SKIN

Explore this box plot interactively →