TMEM70

Across TCGA patient cohorts, TMEM70 mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM70-associated genes across cancer lineages are CCNYL3, MTND6P20, and PPATP2. Each is linked with TMEM70 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM70-to-partner and partner-to-TMEM70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNYL3 grouped by TMEM70-low versus TMEM70-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM70→partner) and Y-score (partner→TMEM70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CCNYL3 →	+0.044	+7.640	<.001	.009	3	2
BLCA	MTND6P20 →	+0.104	+7.640	<.001	.009	3	2
BLCA	PPATP2 →	+0.099	+7.640	<.001	.009	3	2
COAD	OR6M3P →	+0.700	+5.693	<.001	.003	3	2
BLCA	RN7SKP113 →	+0.143	+7.640	<.001	.009	3	1
BLCA	RNU6-596P →	+0.368	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

CCNYL3 by TMEM70 expression — BLCA

Explore this box plot interactively →