TMEM70

Across TCGA patient cohorts, TMEM70 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM70-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and JNK2. Each is linked with TMEM70 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM70-to-partner and partner-to-TMEM70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM70-low versus TMEM70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM70→partner) and Y-score (partner→TMEM70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.333	-3.000	.021	.037	3	1
UCEC	FoxM1 →	+0.341	+3.000	.022	.037	3	1
UCEC	JNK2 →	+0.262	+3.000	.022	.037	3	1
UCEC	N-Ras →	-0.196	-2.986	.004	.037	3	1
UCEC	TFRC →	+0.682	+3.000	.026	.037	2	2
UCEC	Caspase-8 →	-0.292	-3.000	.044	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by TMEM70 expression — UCEC

Explore this box plot interactively →