TMEM70

Across TCGA cell cohorts, TMEM70 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,442 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM70-associated GO terms across cancer lineages are Mitochondrial ribosome assembly, rRNA pseudouridine synthesis, and Regulation of establishment of protein localization to chromosome. Each is linked with TMEM70 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM70-to-partner and partner-to-TMEM70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial ribosome assembly grouped by TMEM70-low versus TMEM70-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM70→partner) and Y-score (partner→TMEM70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitochondrial ribosome assembly →	+0.093	+1.029	.006	<.001	3	11
BONE	rRNA pseudouridine synthesis →	+0.096	+0.860	<.001	.002	3	10
LIVER	Regulation of establishment of protein localization to chromosome →	+0.111	+0.607	<.001	.004	3	10
BONE	Mitochondrial large ribosomal subunit assembly →	+0.121	+1.141	<.001	<.001	3	9
CNS	Positive regulation of protein localization to endoplasmic reticulum →	+0.103	+0.483	<.001	.001	3	9
LARGE_INTESTINE	Pteridine-containing compound metabolic process →	+0.081	+0.684	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,442 associations by consensus.

Mitochondrial ribosome assembly by TMEM70 expression — BONE

Explore this box plot interactively →