TMEM68

Across TCGA pan-cancer cohorts, TMEM68 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMEM68 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM68 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM68 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

COAD, HNSC, and PDAC are the cancer types where TMEM68 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.930	.023	36	view →
HNSC	DFS	Median	All	0.231	0.818	.004	14	view →
PDAC	OS	Median	IV	0.405	0.828	.038	3	view →
LSCC	DFS	Tertile	II,III,IV	0.399	1.000	.040	2	view →
CCRCC	DFS	Median	IV	0.382	0.932	.031	1	view →
GBM	OS	Quartile	All	0.968	0.759	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMEM68–COAD (DFS)

Open the COAD breakdown →