TMEM68

Across TCGA pan-cancer cohorts, TMEM68 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM68’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM68 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM68 is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

HNSC, PDAC, and COAD are the cancer types where TMEM68 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM68 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.203	.002	8	view →
PDAC	Female	II,III,IV	−0.811	<.001	5	view →
COAD	All	All	−0.173	.019	5	view →
LSCC	All	All	+0.079	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TMEM68–HNSC

Open the HNSC breakdown →