TMEM68

Across TCGA cell cohorts, TMEM68 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM68-associated genes across cancer lineages are GFRA4, TBC1D21, and OR4F4. Each is linked with TMEM68 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM68-to-partner and partner-to-TMEM68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by TMEM68-low versus TMEM68-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM68→partner) and Y-score (partner→TMEM68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR4F4 →	+0.018	+3.688	<.001	.002	3	1
LARGE_INTESTINE	PSMB11 →	+0.025	+3.878	<.001	.003	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GFRA4 by TMEM68 expression — LARGE_INTESTINE

Explore this box plot interactively →