TMEM67

Across TCGA patient cohorts, TMEM67 mutation is significantly associated with the RNA expression of many other genes, with 2,751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM67-associated genes across cancer lineages are MTND4LP21, FBXW5, and MFSD12. Each is linked with TMEM67 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM67-to-partner and partner-to-TMEM67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4LP21 grouped by TMEM67-low versus TMEM67-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM67→partner) and Y-score (partner→TMEM67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	MTND4LP21 →	+0.136	+5.770	<.001	.003	3	3
SKCM	FBXW5 →	+0.468	+2.366	.006	.003	3	3
SKCM	MFSD12 →	+0.902	+2.497	.003	.009	3	3
UCEC	PKMYT1 →	+0.597	+1.698	<.001	<.001	3	3
UCEC	ACTR1A →	+0.285	+2.087	.001	.005	3	3
HNSC	CCDC58P2 →	+0.137	+6.111	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,751 associations by consensus.

MTND4LP21 by TMEM67 expression — KIRP

Explore this box plot interactively →