TMEM67

Across TCGA patient cohorts, TMEM67 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM67-associated genes across cancer lineages are Heregulin, LKB1, and CDK1. Each is linked with TMEM67 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM67-to-partner and partner-to-TMEM67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by TMEM67-low versus TMEM67-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM67→partner) and Y-score (partner→TMEM67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Heregulin →	+0.156	+2.820	.049	.035	3	2
SKCM	LKB1 →	+0.156	+3.700	.003	.001	3	2
SKCM	CDK1 →	+0.342	+3.169	<.001	.018	3	2
SKCM	Chk2_pT68 →	+0.186	+3.182	.010	.009	3	2
UCEC	MSH2 →	-0.188	-1.973	.009	.008	3	2
UCEC	p27_pT198 →	+0.068	+1.584	.044	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Heregulin by TMEM67 expression — SKCM

Explore this box plot interactively →