TMEM67

Across TCGA cell cohorts, TMEM67 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,109 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM67-associated GO terms across cancer lineages are Protein localization to cilium, Protein localization to non-motile cilium, and Protein localization to ciliary transition zone. Each is linked with TMEM67 in more than 18 cancer types. Because this analysis shows association rather than direction, both TMEM67-to-partner and partner-to-TMEM67 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cilium grouped by TMEM67-low versus TMEM67-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM67→partner) and Y-score (partner→TMEM67) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein localization to cilium →	+0.080	+1.170	<.001	<.001	3	19
STOMACH	Protein localization to non-motile cilium →	+0.097	+1.573	<.001	<.001	3	16
BREAST	Protein localization to ciliary transition zone →	+0.109	+1.290	<.001	<.001	3	16
OESOPHAGUS	Microtubule-based transport →	+0.038	+1.049	.004	.001	3	15
LUNG_NSCLC_LUAD	Negative regulation of centrosome duplication →	+0.096	+0.727	<.001	<.001	3	15
LUNG_NSCLC_LUAD	Negative regulation of centrosome cycle →	+0.096	+0.727	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

Protein localization to cilium by TMEM67 expression — LIVER

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