TMEM63C

Across TCGA patient cohorts, TMEM63C mutation is significantly associated with the RNA expression of many other genes, with 3,258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM63C-associated genes across cancer lineages are MIR6801, AZGP1, and GFI1. Each is linked with TMEM63C in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM63C-to-partner and partner-to-TMEM63C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6801 grouped by TMEM63C-low versus TMEM63C-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63C→partner) and Y-score (partner→TMEM63C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR6801 →	+0.663	+4.656	<.001	<.001	3	4
UCEC	AZGP1 →	-0.872	-2.864	.003	.001	3	3
COAD	GFI1 →	+0.847	+3.727	.002	<.001	3	3
UCEC	NIPA1 →	+0.781	+1.914	<.001	<.001	3	3
UCEC	RAD51 →	+0.779	+1.903	<.001	<.001	3	3
UCEC	SF3B2 →	+0.447	+1.903	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,258 associations by consensus.

MIR6801 by TMEM63C expression — LUSC

Explore this box plot interactively →