TMEM63C

Across TCGA patient cohorts, TMEM63C mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM63C-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with TMEM63C in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM63C-to-partner and partner-to-TMEM63C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TMEM63C-low versus TMEM63C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63C→partner) and Y-score (partner→TMEM63C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.517	-2.584	.001	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.691	+2.434	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.240	-1.514	.004	.015	3	2
UCEC	mTOR_pS2448 →	-0.136	-2.202	.007	.010	3	2
UCEC	Annexin-1 →	+0.415	+1.720	.020	.025	3	2
UCEC	TFRC →	+0.476	+2.321	.008	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PDCD4 by TMEM63C expression — UCEC

Explore this box plot interactively →