TMEM63C

Across TCGA cell cohorts, TMEM63C mutation is significantly associated with the RNA expression of many other genes, with 816 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM63C-associated genes across cancer lineages are CCNJ, ANAPC4, and NCKAP1. Each is linked with TMEM63C in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM63C-to-partner and partner-to-TMEM63C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNJ grouped by TMEM63C-low versus TMEM63C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM63C→partner) and Y-score (partner→TMEM63C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCNJ →	+0.659	+2.502	.001	.005	3	2
LARGE_INTESTINE	ANAPC4 →	+0.637	+2.588	<.001	.004	3	2
LARGE_INTESTINE	NCKAP1 →	+0.546	+3.321	<.001	.002	3	2
URINARY_TRACT	OR2A2 →	+0.035	+4.087	<.001	.009	3	1
URINARY_TRACT	FCN1 →	+0.010	+4.087	<.001	.009	3	1
PANCREAS	MYF5 →	+0.016	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 816 associations by consensus.

CCNJ by TMEM63C expression — LARGE_INTESTINE

Explore this box plot interactively →