TMEM60

Across TCGA pan-cancer cohorts, TMEM60 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM60 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM60 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMEM60 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where TMEM60 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.990	0.890	.024	4	view →
PDAC	OS	Median	All	0.958	0.694	.021	3	view →
LSCC	OS	Quartile	II,III,IV	0.927	0.541	.033	2	view →
CCRCC	DFS	Median	All	0.624	1.000	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM60–UCEC (OS)

Open the UCEC breakdown →