TMEM60

Across TCGA cell cohorts, TMEM60 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,915 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM60-associated GO terms across cancer lineages are Peptidyl-glutamic acid carboxylation, Protein carboxylation, and Cytoplasm protein quality control. Each is linked with TMEM60 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM60-to-partner and partner-to-TMEM60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-glutamic acid carboxylation grouped by TMEM60-low versus TMEM60-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM60→partner) and Y-score (partner→TMEM60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Peptidyl-glutamic acid carboxylation →	+0.122	+0.990	<.001	<.001	3	12
OVARY	Protein carboxylation →	+0.122	+0.990	<.001	<.001	3	12
BONE	Cytoplasm protein quality control →	-0.147	-0.773	<.001	.002	3	11
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	-0.177	-0.942	.001	<.001	2	12
CNS	Mitochondrial respirasome assembly →	+0.108	+0.592	<.001	<.001	3	9
BONE	rRNA metabolic process →	-0.095	-0.754	.002	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,915 associations by consensus.

Peptidyl-glutamic acid carboxylation by TMEM60 expression — OVARY

Explore this box plot interactively →