TMEM59

Across TCGA pan-cancer cohorts, TMEM59 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM59 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TMEM59 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM59 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

LUAD, HNSC, and COAD are the cancer types where TMEM59 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	0.300	0.781	.006	20	view →
HNSC	DFS	Median	II,III,IV	0.989	0.902	.018	15	view →
COAD	DFS	Median	All	1.000	0.887	.022	12	view →
CCRCC	OS	Tertile	All	0.778	0.966	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM59–LUAD (DFS)

Open the LUAD breakdown →