TMEM59

Across TCGA patient cohorts, TMEM59 protein abundance is significantly associated with the RNA expression of many other genes, with 7,801 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM59-associated genes across cancer lineages are GPRC5C, DHRS3, and ATP6V0B. Each is linked with TMEM59 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM59-to-partner and partner-to-TMEM59 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM59 versus GPRC5C in OV, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59→partner) and Y-score (partner→TMEM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GPRC5C →	+1.467	+0.666	<.001	<.001	3	4
LSCC	DHRS3 →	+0.914	+0.333	<.001	<.001	3	3
PDAC	ATP6V0B →	+0.423	+0.584	.002	<.001	3	3
BRCA	TSPAN1 →	+1.778	+0.416	<.001	<.001	3	3
PDAC	DHCR24 →	+0.779	+0.428	.001	.002	3	3
UCEC	CEP152 →	-0.691	-0.410	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,801 associations by consensus.

TMEM59 vs GPRC5C — OV

Explore this scatter interactively →