TMEM59

Across TCGA patient cohorts, TMEM59 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM59-associated genes across cancer lineages are p27_pT198, EGFR_pY1068, and EGFR. Each is linked with TMEM59 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM59-to-partner and partner-to-TMEM59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by TMEM59-low versus TMEM59-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59→partner) and Y-score (partner→TMEM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.102	+3.700	.014	.001	3	2
UCEC	EGFR_pY1068 →	-0.223	-2.459	.023	.018	3	1
UCEC	EGFR →	-0.138	-2.000	.028	.010	3	1
UCEC	eIF4E →	+0.197	+2.459	.017	.019	3	1
UCEC	INPP4B →	-0.289	-1.874	.023	.049	3	1
UCEC	JNK2 →	+0.218	+2.000	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

p27_pT198 by TMEM59 expression — UCEC

Explore this box plot interactively →