TMEM59

Across TCGA cell cohorts, TMEM59 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,127 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM59-associated GO terms across cancer lineages are Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), XMP metabolic process, and XMP biosynthetic process. Each is linked with TMEM59 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMEM59-to-partner and partner-to-TMEM59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by TMEM59-low versus TMEM59-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59→partner) and Y-score (partner→TMEM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.208	-1.379	<.001	<.001	3	14
BONE	XMP metabolic process →	-0.188	-1.062	<.001	<.001	3	14
BONE	XMP biosynthetic process →	-0.188	-1.062	<.001	<.001	3	14
BONE	'de novo' XMP biosynthetic process →	-0.188	-1.062	<.001	<.001	3	14
BONE	Regulation of protein localization to membrane →	+0.108	+1.283	<.001	<.001	3	14
BONE	Protein exit from endoplasmic reticulum →	+0.144	+1.213	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,127 associations by consensus.

Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by TMEM59 expression — BONE

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