TMEM59

Across TCGA cell cohorts, TMEM59 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM59-associated genes across cancer lineages are R3HDML, AVP, and BANF2. Each is linked with TMEM59 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM59-to-partner and partner-to-TMEM59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by TMEM59-low versus TMEM59-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM59→partner) and Y-score (partner→TMEM59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.047	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	ETDC →	+0.483	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	C20orf173 →	+0.060	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.025	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

R3HDML by TMEM59 expression — BLOOD_Lymphoma

Explore this box plot interactively →