TMEM54

Across TCGA pan-cancer cohorts, TMEM54 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM54 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher TMEM54 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM54 expression acts as an unfavorable survival marker.

DLBC, KIRC, and SKCM are the cancer types where TMEM54 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
KIRC	OS	Median	All	0.249	0.805	.010	12	view →
SKCM	DFS	Median	All	0.192	0.757	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM54–DLBC (DFS)

Open the DLBC breakdown →