TMEM54

Across TCGA pan-cancer cohorts, TMEM54 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM54 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM54 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM54 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC and GBM are the cancer types where TMEM54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	1.000	0.781	.036	6	view →
GBM	OS	Tertile	All	0.818	0.462	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM54–HNSC (DFS)

Open the HNSC breakdown →