TMEM54

Across TCGA cell cohorts, TMEM54 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,440 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM54-associated GO terms across cancer lineages are Cytokinetic process, ERBB3 signaling pathway, and ERBB2-ERBB3 signaling pathway. Each is linked with TMEM54 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM54-to-partner and partner-to-TMEM54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytokinetic process grouped by TMEM54-low versus TMEM54-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM54→partner) and Y-score (partner→TMEM54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytokinetic process →	+0.080	+0.740	.001	.004	3	9
STOMACH	ERBB3 signaling pathway →	+0.175	+1.697	<.001	.004	3	9
STOMACH	ERBB2-ERBB3 signaling pathway →	+0.175	+1.697	<.001	.004	3	9
STOMACH	Protein localization to plasma membrane →	+0.073	+2.020	<.001	.006	3	9
STOMACH	T cell mediated cytotoxicity →	+0.193	+1.795	<.001	.003	3	9
LUNG_SCLC	tRNA 3'-terminal CCA addition →	-0.107	-1.912	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,440 associations by consensus.

Cytokinetic process by TMEM54 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →