TMEM52B

Across TCGA pan-cancer cohorts, TMEM52B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM52B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TMEM52B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM52B expression acts as an unfavorable survival marker.

CESC, LGG, and ESCA are the cancer types where TMEM52B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.083	0.543	.013	12	view →
LGG	OS	Median	All	0.204	0.810	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.306	0.707	.008	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM52B–CESC (DFS)

Open the CESC breakdown →