TMEM51

Across TCGA patient cohorts, TMEM51 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TMEM51-associated genes across cancer lineages are RNU2-8P, MIR107, and MIR944. Each is linked with TMEM51 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM51-to-partner and partner-to-TMEM51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-8P grouped by TMEM51-low versus TMEM51-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM51→partner) and Y-score (partner→TMEM51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU2-8P →	+0.437	+7.741	<.001	.009	3	3
CESC	MIR107 →	+0.146	+4.516	<.001	.004	3	2
COAD	MIR944 →	+1.591	+7.741	<.001	.009	3	2
CESC	RN7SKP140 →	+0.055	+4.516	<.001	.004	3	2
CESC	DDX6P1 →	+0.014	+4.003	.001	.002	3	2
CESC	OR11I1P →	+0.018	+4.842	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

RNU2-8P by TMEM51 expression — COAD

Explore this box plot interactively →