TMEM51

Across TCGA patient cohorts, TMEM51 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM51-associated genes across cancer lineages are EGFR_pY1068, MSH2, and Notch1. Each is linked with TMEM51 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM51-to-partner and partner-to-TMEM51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM51-low versus TMEM51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM51→partner) and Y-score (partner→TMEM51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.301	-3.169	.029	.020	3	1
UCEC	MSH2 →	-0.409	-2.973	.001	.035	3	1
UCEC	Notch1 →	+0.264	+3.169	<.001	.020	3	1
UCEC	PEA-15_pS116 →	+0.488	+3.169	.011	.020	3	1
UCEC	Smac →	+0.291	+3.169	.042	.020	3	1
UCEC	TFRC →	+0.798	+3.169	.006	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by TMEM51 expression — UCEC

Explore this box plot interactively →