TMEM51

Across TCGA cell cohorts, TMEM51 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,475 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM51-associated GO terms across cancer lineages are Negative regulation of defense response, Leukocyte apoptotic process, and Canonical NF-kappaB signal transduction. Each is linked with TMEM51 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM51-to-partner and partner-to-TMEM51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of defense response grouped by TMEM51-low versus TMEM51-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM51→partner) and Y-score (partner→TMEM51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of defense response →	+0.059	+1.398	<.001	<.001	3	12
URINARY_TRACT	Leukocyte apoptotic process →	+0.106	+1.246	.003	.006	3	11
LUNG_NSCLC_LUSC	Canonical NF-kappaB signal transduction →	+0.138	+1.745	<.001	<.001	3	10
BONE	Protein processing →	+0.085	+2.022	.008	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of lamellipodium organization →	+0.115	+1.384	.003	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of tumor necrosis factor superfamily cytokine production →	+0.093	+1.477	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,475 associations by consensus.

Negative regulation of defense response by TMEM51 expression — PANCREAS

Explore this box plot interactively →