TMEM47

Across TCGA pan-cancer cohorts, TMEM47 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM47 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher TMEM47 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM47 expression acts as an unfavorable survival marker.

DLBC, ESCA, and UCEC are the cancer types where TMEM47 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.097	0.633	.007	6	view →
ESCA	OS	Median	II,III,IV	0.226	0.686	.013	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM47–DLBC (DFS)

Open the DLBC breakdown →