TMEM47

Across TCGA patient cohorts, TMEM47 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM47-associated genes across cancer lineages are ATM, PDCD4, and Rad50. Each is linked with TMEM47 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM47-to-partner and partner-to-TMEM47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TMEM47-low versus TMEM47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM47→partner) and Y-score (partner→TMEM47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.352	-2.102	.018	.016	3	3
UCEC	PDCD4 →	-0.365	-1.405	.018	.043	3	2
UCEC	Rad50 →	-0.178	-1.652	.025	.006	3	2
UCEC	Annexin-1 →	+0.570	+1.938	.001	.001	3	2
UCEC	ASNS →	+0.268	+1.678	.024	.021	3	2
UCEC	14-3-3_beta →	-0.094	-2.295	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by TMEM47 expression — UCEC

Explore this box plot interactively →