TMEM45B

Across TCGA pan-cancer cohorts, TMEM45B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM45B data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM45B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM45B expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where TMEM45B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.655	.006	10	view →
HNSC	OS	Tertile	All	0.861	0.577	.010	10	view →
LUAD	OS	Quartile	All	0.344	0.848	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM45B–UCEC (DFS)

Open the UCEC breakdown →