TMEM44-AS1

Across TCGA pan-cancer cohorts, TMEM44-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM44-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TMEM44-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM44-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and LUSC show a favorable association.

ACC, UVM, and LIHC are the cancer types where TMEM44-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.356	0.714	<.001	66	view →
UVM	DFS	Tertile	II,III,IV	0.850	0.465	.003	39	view →
LIHC	OS	Tertile	All	0.685	0.880	<.001	37	view →
LUSC	OS	Quartile	All	0.851	0.679	<.001	34	view →
STAD	DFS	Median	IV	0.187	0.656	.005	31	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.209	.014	13	view →
BLCA	DFS	Tertile	IV	0.272	0.604	.031	12	view →
MESO	DFS	Quartile	All	0.205	0.675	.006	12	view →
READ	DFS	Quartile	IV	0.340	1.000	.006	12	view →
SKCM	DFS	Quartile	II,III,IV	0.752	0.598	.012	10	view →
KIRC	DFS	Quartile	II,III,IV	0.667	0.855	.004	9	view →
COAD	DFS	Median	IV	0.368	0.613	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM44-AS1–ACC (DFS)

Open the ACC breakdown →