TMEM43

Across TCGA pan-cancer cohorts, TMEM43 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM43 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TMEM43 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM43 expression acts as an unfavorable survival marker.

OV, SKCM, and UCEC are the cancer types where TMEM43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	II,III,IV	0.209	0.541	.020	18	view →
SKCM	DFS	Median	III,IV	0.029	0.597	<.001	10	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM43–OV (DFS)

Open the OV breakdown →