TMEM43

Across TCGA pan-cancer cohorts, TMEM43 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMEM43 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM43 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM43 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where TMEM43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	34	view →
PDAC	DFS	Median	All	0.331	0.483	.012	15	view →
CCRCC	OS	Median	III,IV	0.202	0.985	.007	13	view →
HNSC	DFS	Median	III,IV	0.750	0.502	.011	11	view →
LUAD	DFS	Tertile	All	0.699	1.000	.010	8	view →
GBM	OS	Tertile	All	0.749	0.880	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMEM43–UCEC (OS)

Open the UCEC breakdown →