TMEM43

Across TCGA patient cohorts, TMEM43 protein abundance is significantly associated with the protein abundance of many other proteins, with 20,145 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM43-associated proteins across cancer lineages are TMTC3, RTN4, and ANO6. Each is linked with TMEM43 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM43-to-partner and partner-to-TMEM43 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM43 versus TMTC3 in UCEC, with a Pearson correlation of 0.69.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM43→partner) and Y-score (partner→TMEM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMTC3 →	+0.461	+0.424	<.001	<.001	3	9
BRCA	RTN4 →	+0.373	+0.544	<.001	<.001	3	9
UCEC	ANO6 →	+0.578	+0.601	<.001	<.001	3	9
CCRCC	NCLN →	+0.361	+0.509	<.001	<.001	3	8
BRCA	ATL3 →	+0.402	+0.372	<.001	<.001	3	8
UCEC	ESYT1 →	+0.324	+0.394	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,145 associations by consensus.

TMEM43 vs TMTC3 — UCEC

Explore this scatter interactively →