TMEM43

Across TCGA patient cohorts, TMEM43 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM43-associated genes across cancer lineages are Bak, c-Met_pY1235, and Smac. Each is linked with TMEM43 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM43-to-partner and partner-to-TMEM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by TMEM43-low versus TMEM43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM43→partner) and Y-score (partner→TMEM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.327	+3.169	.012	.019	3	2
UCEC	c-Met_pY1235 →	+0.101	+3.009	.009	.019	3	2
SKCM	Smac →	+0.337	+2.824	.040	.036	3	1
UCEC	VHL →	-0.889	-3.321	.012	.010	3	1
UCEC	ATM →	-0.476	-3.321	.045	.010	2	2
SKCM	p53 →	+0.250	+2.824	.027	.036	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Bak by TMEM43 expression — UCEC

Explore this box plot interactively →