TMEM43

Across TCGA cell cohorts, TMEM43 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,736 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM43-associated GO terms across cancer lineages are Skeletal muscle fiber development, Regulation of cell-matrix adhesion, and Regulation of focal adhesion assembly. Each is linked with TMEM43 in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM43-to-partner and partner-to-TMEM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Skeletal muscle fiber development grouped by TMEM43-low versus TMEM43-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM43→partner) and Y-score (partner→TMEM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Skeletal muscle fiber development →	+0.203	+0.855	<.001	<.001	3	15
BONE	Regulation of cell-matrix adhesion →	+0.141	+1.048	<.001	<.001	3	15
BONE	Regulation of focal adhesion assembly →	+0.155	+1.121	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.155	+1.121	<.001	<.001	3	14
BONE	Amyloid-beta clearance by transcytosis →	+0.212	+1.205	<.001	.001	3	14
BREAST	Viral process →	+0.084	+1.178	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,736 associations by consensus.

Skeletal muscle fiber development by TMEM43 expression — SOFT_TISSUE

Explore this box plot interactively →