TMEM42

Across TCGA pan-cancer cohorts, TMEM42 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM42 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TMEM42 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM42 expression acts as an unfavorable survival marker.

STAD and LIHC are the cancer types where TMEM42 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.222	0.729	.004	12	view →
LIHC	OS	Median	All	0.258	0.773	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM42–STAD (OS)

Open the STAD breakdown →