TMEM42

Across TCGA patient cohorts, TMEM42 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM42-associated genes across cancer lineages are CD8+ Tem and CD4+ naive T-cells. Each is linked with TMEM42 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM42-to-partner and partner-to-TMEM42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by TMEM42-low versus TMEM42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM42→partner) and Y-score (partner→TMEM42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tem →	+0.004	+4.744	<.001	.040	3	1
UCEC	CD4+ naive T-cells →	+0.010	+2.682	<.001	.048	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ Tem by TMEM42 expression — UCEC

Explore this box plot interactively →