TMEM42

Across TCGA cell cohorts, TMEM42 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,224 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM42-associated GO terms across cancer lineages are Positive regulation of CD8-positive, alpha-beta T cell proliferation, Spermidine biosynthetic process, and Negative regulation of lymphocyte mediated immunity. Each is linked with TMEM42 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM42-to-partner and partner-to-TMEM42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of CD8-positive, alpha-beta T cell proliferation grouped by TMEM42-low versus TMEM42-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM42→partner) and Y-score (partner→TMEM42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of CD8-positive, alpha-beta T cell proliferation →	+0.219	+0.930	.002	.005	3	11
PANCREAS	Spermidine biosynthetic process →	-0.104	-0.833	.003	<.001	3	8
SOFT_TISSUE	Negative regulation of lymphocyte mediated immunity →	+0.196	+1.305	<.001	<.001	3	8
LIVER	Glycine decarboxylation via glycine cleavage system →	-0.364	-1.363	<.001	.001	3	7
LIVER	Glycine catabolic process →	-0.364	-1.363	<.001	.001	3	7
BREAST	Regulation of T cell anergy →	+0.615	+0.627	.003	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,224 associations by consensus.

Positive regulation of CD8-positive, alpha-beta T cell proliferation by TMEM42 expression — SOFT_TISSUE

Explore this box plot interactively →