TMEM41B

Across TCGA pan-cancer cohorts, TMEM41B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMEM41B data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM41B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM41B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where TMEM41B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.837	0.486	<.001	41	view →
CCRCC	DFS	Tertile	III,IV	0.548	0.849	.010	21	view →
LUAD	DFS	Quartile	All	0.889	0.337	.004	19	view →
GBM	DFS	Tertile	All	0.498	0.258	.003	9	view →
UCEC	DFS	Median	II,III,IV	0.448	1.000	.040	4	view →
LSCC	OS	Tertile	All	0.980	0.877	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMEM41B–HNSC (DFS)

Open the HNSC breakdown →