TMEM41B

Across TCGA patient cohorts, TMEM41B mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM41B-associated genes across cancer lineages are DFFA, TONSL, and PDZD8. Each is linked with TMEM41B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM41B-to-partner and partner-to-TMEM41B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DFFA grouped by TMEM41B-low versus TMEM41B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM41B→partner) and Y-score (partner→TMEM41B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DFFA →	+0.584	+3.223	.003	.009	3	1
UCEC	TONSL →	+0.946	+3.212	.001	.009	3	1
UCEC	PDZD8 →	+1.185	+3.209	<.001	.009	3	1
UCEC	TRAPPC2L →	+0.541	+3.245	.005	.009	3	1
UCEC	C19orf48 →	+0.952	+3.255	<.001	.009	3	1
UCEC	ATOH1 →	+0.632	+3.151	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

DFFA by TMEM41B expression — UCEC

Explore this box plot interactively →